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ea0099rc3.6 | Rapid Communications 3: Adrenal and Cardiovascular Endocrinology | Part I | ECE2024

Mismatch repair deficiency and microsatellite instability in adrenocortical carcinoma: Diagnosis, prevalence, and clinical impact

Altieri Barbara , Herterich Sabine , Kircher Stefan , Jahn Arne , Teleanu Maria-Veronica , Lippert Juliane , Landwehr Laura-Sophie , Kimpel Otilia , Reuter Miriam , Remde Hanna , Stenzinger Albrecht , Glimm Hanno , Bargou Ralf , Froehling Stefan , Ronchi Cristina L , Appenzeller Silke , Fassnacht Martin , Matthias Kroiss

Background: DNA mismatch repair (MMR) maintains genomic integrity and stability. Inactivation of the MMR genes MLH1, PMS2, MSH2, and MSH6 by somatic or germline variants or gene methylation causes MMR deficiency (dMMR) leading to microsatellite instability (MSI) and high tumour mutational burden. In many tumour entities, patients with dMMR/MSI respond well to immune checkpoint inhibitor (ICI) therapy. The clinical relevance of dMMR and MSI i...

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ea0099p505 | Endocrine-Related Cancer | ECE2024

Growth differentiation factor 15 (GDF-15) is induced by mitotane in adrenocortical carcinoma and associated with poor prognosis and impaired responsiveness to immunotherapy

Weigand Isabel , Triebig Alexandra , Tanja Maier , Anderlik Tanja , Remde Hanna , Landwehr Laura-Sophie , Kimpel Otilia , Reuter Miriam , Schreiner Jochen , Wedekink Florian , Hoster Eva , Schwarzlmueller Paul , Reincke Martin , Wischhusen Jorg , Fassnacht Martin , Matthias Kroiss

Background: Treatment of adrenocortical carcinoma (ACC) is unsatisfactory in advanced stages. Oral mitotane remains a mainstay of treatment. Response rates of ACC to immune checkpoint inhibition (ICI) are disappointing and markers of response have not been identified. Tumoural infiltration with cells of the adaptive immune system is sparse in ACC tissue. Growth/differentiation factor 15 (GDF-15) is a cytokine that has been described to impair tumoral immune infiltration and is...

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ea0099rc3.2 | Rapid Communications 3: Adrenal and Cardiovascular Endocrinology | Part I | ECE2024

Combined [18F]Fluorodeoxyglucose PET and [123I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias – The prospective cross-sectional diagnostic test performance study FAMIAN

Hahner Stefanie , Hartrampf Philipp , Beuschlein Felix , Miederer Matthias , Miehle Konstanze , Wiebke Schlotelburg , Fuss Carmina Teresa , Pflmger Thomas , Fottner Christian , Tonjes Anke , Herrmann Ken , Amthauer Holger , Schreckenberger Mathias , Sabri Osama , Werner Johanna , Reuter Miriam , Kircher Stefan , Arlt Wiebke , Fassnacht Martin , Buck Andreas , Muller Hans Helge , Andreas Schirbel

Adrenal tumours are frequently detected by conventional cross-sectional imaging, which, however, has limited specificity in identifying the most prevalent tumour type, benign, non-functional adrenocortical adenomas (ACA) not requiring surgery. We assessed the diagnostic accuracy of adrenal molecular imaging with [18F]Fluorodeoxyglucose-positron emission tomography (FDG-PET) and [123I]Iodometomidate-single photon emission tomography (IMTO-SPECT). We perfor...

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Endocrine Abstracts

Mismatch repair deficiency and microsatellite instability in adrenocortical carcinoma: Diagnosis, prevalence, and clinical impact

Growth differentiation factor 15 (GDF-15) is induced by mitotane in adrenocortical carcinoma and associated with poor prognosis and impaired responsiveness to immunotherapy

Combined [18F]Fluorodeoxyglucose PET and [123I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias – The prospective cross-sectional diagnostic test performance study FAMIAN

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